Chair, Department of Surgery
The Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
The John Rhea Barton Professor and Chair of the Department of Surgery at the University of Pennsylvania. Dr. DeMatteo is a surgical oncologist who is nationally recognized for his expertise in treating diseases of the liver, bile duct, gallbladder, pancreas, abdominal sarcomas, and gastrointestinal stromal tumors (GIST). His clinical research is focused on liver, bile duct, gallbladder, and pancreas cancers. Dr. DeMatteo completed his surgical residency and two postdoctoral fellowships at Penn Medicine – in Molecular Biology and Virology with Steven E. Raper, MD and James M. Wilson, MD, PhD; and in Immunology and Transplantation with Clyde F. Barker, MD – and returned in July 2017 as Chair of Surgery, after 20 years spent at Memorial Sloan Kettering Cancer Center (MSKCC). He most recently served as Vice Chair of the Department of Surgery and Head of the Division of General Surgical Oncology at MSKCC. He was also Professor of Surgery and Associate Dean at Weill Medical College of Cornell University. At Penn, Dr. DeMatteo leads 130 faculty across 11 divisions who provide advanced patient care and conduct a robust portfolio of basic and clinical research.
Over the course of his career, Dr. DeMatteo has made significant research advances studying the immune environment of the liver and tumor immunology, and working to develop immune therapies to help prevent tumors from returning after surgery. He has served as the principal investigator on three national trials of the adjuvant drug imatinib following surgery to remove gastrointestinal stromal tumors, leading to its approval by the U.S. Food and Drug Administration and a new standard of care for the disease. A well-respected educator, Dr. DeMatteo was Director of the Surgical Oncology Fellowship Program for seven years at MSKCC, and he has mentored more than 135 clinical and laboratory fellows.
P68: Systemic Treg depletion inhibits tumor growth in gastrointestinal stromal tumor (GIST)
Thursday, March 21, 2024
3:28pm – 3:34pm ET
Friday, March 22, 2024
2:30pm – 4:00pm ET