E285: Older Age Does Not Increase Inpatient Complications After Pancreatectomy

ePoster Abstract Author(s)

Oguz Aras, MD

Research Fellow
Guthrie Robert Packer Hospital
Sayre, Pennsylvania, United States

Submitter(s)

Oguz Aras, MD

Research Fellow
Guthrie Robert Packer Hospital
Sayre, Pennsylvania, United States

Author(s)

Oguz Aras, MD

Research Fellow
Guthrie Robert Packer Hospital
Sayre, Pennsylvania, United States
AD

Anseh Danesharasteh, n/a

Graduate Research Assistant
Department of System Science and Industrial Engineering, Binghamton University
Binghamton, New York, United States
ZE

Zeynep Ertem, PhD

Assistant Professor
Department of System Science and Industrial Engineering, Binghamton University
Binghamton, New York, United States
BM

Bryant Morocho, MD

General Surgery Resident
Guthrie Robert Packer Hospital, United States
CB

Ceyda Bertram, MD

General Surgery Resident
Guthrie Robert Packer Hospital, United States
AB

Angela Balagadde, MD

Research Fellow
Guthrie Robert Packer Hospital, United States
AI

Apurva Inamdar, MD

Research Fellow
Guthrie Robert Packer Hospital, United States
RM

Rebekah Macfie, MD

Assistant Professor
Guthrie Robert Packer Hospital, United States

Introduction: As the population ages, septuagenarians and octogenarians are increasingly presenting to undergo evaluation for pancreatectomy. Yet there is little data regarding surgical outcomes of these older patients undergoing pancreatectomy. Here we examine in-hospital complications of patients 70-90yo+ undergoing pancreatectomy from the National Inpatient Sample (NIS).

Methods: The NIS dataset for 2016-2019 was queried for all patients undergoing pancreatectomy. Patients were divided based on age group (70-79, 80-89, 90+ and reference 50-59 and 60-69) and sex. Primary outcome was a composite of post-operative surgical and medical complications (ICD 10 codes: T80 – T88). Random effects linear regression was used to generate slope coefficients to compare complications, length of stay and total charge between age groups and sex.

Results:

12816 patients were identified; 3422 (27%) in the 70-79yo group and 873 (7%) in the 80-89yo (Table 1). There was no significant association between age group 70-79yo, 80-89yo or 90yo+ with major complication compared to age groups 50-59yo and 60-69yo [70-79yo 0.037, 95%CI [-0.11, 0.19]; p=0.6; 80-89yo 0.122 95%CI [-0.13,0.37]; p=0.3]. However there was a protective effect observed for female sex in regards to major complications [-0.27, 95%CI [-0.41, -0.13]; p< 0.001].
There was a slight increase in LOS in the 80-89yo group of 1.1d p=0.002; which was not redemonstrated in analysis of female patients 80-89yo (-0.78d p=0.2). There was a significant increase in total charges in the 80-89yo group [+$14,685 +/- $6726, 95%CI [1499-27869]; p=0.029.]

Conclusions: Short term post-operative complications are similar between age groups, including septuagenarians and octogenarians undergoing pancreatectomy. However, for octogenarians there was a slight increase in LOS and significant increase in total charges- with a protective effect noted of female sex. Further study is warranted, however our findings suggest that pancreatectomy is a reasonable consideration in carefully selected older patients.

Learning Objectives:

describe the effect of advanced age on immediate post-operative outcomes of pancreatectomy.
describe the differences in post-operative length of hospital stay in several older age cohorts after pancreatectomy.
recall the effect of male or female sex on risk of developing a major complication, length and cost of hospital stay after pancreatectomy.